Resiniferatoxin,57444-62-9

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Resiniferatoxin

CAS No. : 57444-62-9

MCE 国际站：Resiniferatoxin

产品活性：Resiniferatoxin ((+)-Resiniferatoxin)，是一种选择性 TRPV1 受体激动剂，能够从 Euphorbia resinifera 植物中提取得到。在动物模型中，Resiniferatoxin 能够在相当长的一段时间内消除 TRPV1+ 初级感觉传入和钝性心脏交感传入反射。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：TRP Channel

In Vitro: Resiniferatoxin causes extremely prolonged channel opening and calcium influx, which results in cytotoxicity to the TRPV1-positive pain fibers or cell bodies.

In Vivo: Resiniferatoxin (2 μg/10 μl; injected intrathecally into the T2/T3 interspace; four weeks after coronary artery occlusion to induce heart failure in rats) significantly and selectively abolishes the afferent markers expression (TRPV1 and calcitonin gene-related peptide) in dorsal horn and reduced overactivated CSNA. Resiniferatoxin significantly reverses the prolongation of action potential duration (APD) and APD alternan, reduces the inducibilities of ventricular arrhythmias.

相关产品：Natural Product Library Plus  |  Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Rosiglitazone  |  Capsaicin  |  GsMTx4  |  EIPA  |  Probenecid  |  Diphenyleneiodonium chloride  |  2-Aminoethyl diphenylborinate  |  Amiloride hydrochloride  |  GSK1016790A  |  Capsazepine  |  HC-067047  |  HC-030031  |  ML-SA1  |  GSK2193874  |  Adenosine 5′-diphosphoribose sodium  |  AMG9810  |  GSK205  |  SKF-96365 hydrochloride  |  (-)-Menthol  |  Caffeic acid  |  ML-SI1  |  BI-749327  |  GSK2798745  |  Pregnenolone  |  ML-SA5  |  N-(p-amylcinnamoyl) Anthranilic Acid  |  A-967079  |  MK6-83  |  Pico145

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds