一种口服生物有效的信号转导抑制剂Carboxyamidotriazole(CAI)的orotate盐形式。CarboxyamidotriazoleOrotate是一种非电压性钙通道(nonvoltage-operatedcalciumchannels)和钙通道介导的信号通路(calciumchannel-mediatedsignalingpathways)的细胞抑制剂,具有抗癌,抗炎活性和抗血管生成作用。
Carboxyamidotriazole orotate (CTO) is t he orotate salt form of carboxyamidotriazole (CAI), an orally bioavailable small molecule with potential antiangiogenic and antiproliferative activities. Carboxyamidotriazole binds to and inhibits non-voltage-operated calcium channels, blocking both Ca2+ influx into cells and Ca2+ release from intracellular stores, resulting in the disruption of calcium channel-mediated signal transduction. CAI inhibits PI3 activity and vascular endothelial growth factor (VEGF) signaling. This may inhibit endothelial proliferation, tumor cell growth, invasion and metastasis.