一种非电压操纵的钙通道(nonvoltage-operatedcalciumchannels)和钙通道介导的信号通路(calciumchannel-mediatedsignalingpathways)的抑制剂。Carboxyamidotriazole具有抗肿瘤,抗炎和抗血管生成作用。
Carboxyamidotriazole, also known as CAI; RFE-007; NSC-609974; and L-651582, is a novel inhibitor of both cAMP-phosphodiesterases and GMP-phosphodiesterases. Carboxyamidotriazole inhibits oxidative phosphorylation in cancer cells and exerts synergistic anti-cancer effect with glycolysis inhibition. Carboxyamidotriazole ameliorates experimental colitis by inhibition of cytokine production, nuclear factor-κB activation, and colonic fibrosis.