Biotinylated Human IL-17A&17F (C-Avi-6His) (CY87)
产品说明(Description)
Biotinylated Recombinant Human Interleukin-17A/ Interleukin-17F Heterodimer is produced by our Mammalian expression system and the target gene encoding Gly24-Ala155&Arg31-Gln163 is expressed with a Avi tag and a 6His tag at the C-terminus.
Accession #: Q16552&AAH70124.1
Known as: IL‑17A/F Heterodimer; IL-17A&IL-17F Heterodimer
制剂(Formulation)
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.
质量控制(Quality Control)
Purity: Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin: Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
复溶(Reconstitution)
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
保存(Storage)
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
背景(Background)
Human IL-17A&IL-17F is an disulfide-linked heterodimeric glycoprotein comprised of two members of the IL-17 family of cytokines, IL-17A and IL-17F .IL-17A and IL-17F bind to a receptor complex consisting of two IL-17RA chains and one IL-17RC subunit. Genes encoding IL-17A and IL-17F are located on chromosome 6 (6p12) and polymorphisms in these genes were studied in various autoimmune diseases. Previous studies have demonstrated that the G allele of the IL17A gene polymorphism is associated with significantly impaired long-term kidney allograft function and that the GA genotype of the IL17F gene polymorphism is associated with a significantly higher risk of a return to dialysis after kidney transplantation. It ’ s also reported that IL17A gene polymorphism was associated with significantly impaired long-term kidney allograft function, whereas the GA genotype of the IL17F gene polymorphism with a significantly higher risk of graft function loss and return to dialysis after kidney transplantation.
电泳(SDS-PAGE)
FOR RESEARCH USE ONLY