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- 详细信息
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- 库存:
100
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无
- 保修期:
12个月
- 现货状态:
10天
- 供应商:
玉研仪器公司
中国区总代理,国际知名神经痛阈研究仪器知名品牌,上万篇文献
抓力测量仪可以测量大鼠和小鼠的前肢或后肢(通过网格)的抓力(即峰值力和时间阻力)。
抓力测试是对用于大小鼠运动协调和运动功能实验的标准工具。该实验数据法也是对转棒疲劳仪的一个补充。可以评估药物、毒素、肌肉松弛剂、疾病、衰老或神经损伤对肌肉力量的影响。
大鼠、小鼠被放置在抓取工具(T形、梯形或网格)前面的底板上,其高度可调节。杆安装在连接到控制单元的力传感器上,可以独立使用,也可以通过USB端口连接到PC, 通过软件进行监控和数据记录。

型号:47200
主要特点:
· 包含软件
· 带力率监测(通过软件或液晶显示器)
· 包含大鼠和小鼠的抓取工具和抓取网格
· 可调节高度的抓杆/抓梯
· 可选金属网格
· 无需校准
· 最大适用力1500g
· 分辨率0.1g
测试原理及构造:
当尾巴被拉动时,动物会抓住杠杆。 啮齿动物本能地抓住任何它们能抓住的东西,试图阻止这种无意识的向后运动,直到拉力超过它们的抓地力。在动物失去抓握杆的抓地力后,峰值放大器会自动存储四肢达到的峰值拉力并将其显示在显示屏上。
该仪器基本上由黑色喷砂有机玻璃基板组成,配有力传感器和抓取装置(T杆、梯形或可选的网格),可将其定位在可调节的高度。



· 力传感器最大适用力为1500g,分辨率为0.1g。
· 传感器采用专有存储芯片存储所有校准参数,正常使用无需进一步校准;
· 此外,控制器会在每次测量时提示自动归零程序,以自动调整任何偏移。
数据监控和存储:
该设备标配带有内部存储器的控制单元和用于信号监测、数据传输和分析的新型 DCA 软件;
保存后,数据可以在控制单元上浏览和/或以专有的 Excel(.xls) 或文本(.txt) 格式传输到 PC,由市场上的大多数统计分析包进行管理;
GSM 设备旨在使灵敏度实验变得简单和一致,这要归功于它:有效的峰值检测器,可靠和自动检测动物反应;
速率计功能(在控制单元上),确保以一致的速率施加所需的力新软件作为质量控制工具,通过显示施加的拉力(蓝线)、所需的目标力率(黑线)和实时峰值检测(斜率函数)
通过确保蓝色轨迹位于缺失线上,实验者可以始终如一地以所需速率施加力(拉动动物),见图:

抓取网格:
标准包装中包含两个基本的塑料抓栅,用于对小鼠的四肢或后肢(巧妙的盲栅)进行综合测量。
一个金属网格,Cat. No. 47200-327,13x1cm也可作为可选。

参考文献:
- J.D. Lee et alia: “Pharmacological inhibition of comple- ment C5a-C5aR1 signalling ameliorates disease patholo- gy in the hSOD1G93A mouse model of amyotrophic la- teral sclerosis” Br. J. Pharmacol. DOI: 10.1111/bph.13730, 2017
- M. Wiesmann et alia: “A specific dietary intervention to restore brain structure and function after ischemic stro- ke” Theranotics 7 (2): 493-512, 2017
- A. Lenihan et alia: “Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice” Mo- lecular Neurobiology: 1-20, 2016
- G.J. Huang et alia: “Ectopic Cerebellar Cell Migration Cau- ses Maldevel-opment of Purkinje Cells and Abnormal Motor Behaviour in Cxcr4 Null Mice”. PLoS ONE 9 (2): e86471, 2014 (Mouse)
- R. Barone et alia: “Endurance Exercise and Conjuga- ted Linoleic Acid (CLA) Supplementation Up-Regulate CYP17A1 and Stimulate Testostero-ne Biosynthesis” PLoS ONE 8 (11): e79686, 2013 (Mouse)
- N. Lange et alia: “Behavioural and Pharmacological Exa- minations in a Transgenic Mouse Model of 2 early-onset torsion dystonia” Pharmacology, Biochemistry and Beha- vior 97 (4): 647–655, 2011 (Mouse)
- M. Savic et alia: “Behavioural Characterization of Four En- demic Stachys Taxa” Phytother. Res., 2010 (Rat)




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文献和实验1、Bang, Sangsu et al. “GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain.” The Journal of clinical investigation vol. 128,8 (2018): 3568-3582. doi:10.1172/JCI99888
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IF: 17.70
3、Hemed-Shaked, Maayan et al. “MTADV 5-MER peptide suppresses chronic inflammations as well as autoimmune pathologies and unveils a new potential target-Serum Amyloid A.” Journal of autoimmunity vol. 124 (2021): 102713. doi:10.1016/j.jaut.2021.102713
IF: 14.51
4、Romani, Luciana F A et al. “Physicochemical characterization, the Hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samples.” Journal of pharmaceutical analysis vol. 8,2 (2018): 103-108. doi:10.1016/j.jpha.2017.12.006
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6、Allen, Brian D et al. “Hyperadrenocorticism of calorie restriction contributes to its anti-inflammatory action in mice.” Aging cell vol. 18,3 (2019): e12944. doi:10.1111/acel.12944
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7、Mzoughi, Zeineb et al. “Optimized extraction of pectin-like polysaccharide from Suaeda fruticosa leaves: Characterization, antioxidant, anti-inflammatory and analgesic activities.” Carbohydrate polymers vol. 185 (2018): 127-137. doi:10.1016/j.carbpol.2018.01.022
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9、Horváth, Ádám et al. “Analgesic effects of the novel semicarbazide-sensitive amine oxidase inhibitor SZV 1287 in mouse pain models with neuropathic mechanisms: Involvement of transient receptor potential vanilloid 1 and ankyrin 1 receptors.” Pharmacological research vol. 131 (2018): 231-243. doi:10.1016/j.phrs.2018.02.006
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