Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) and a derivative of diclofenac (Item Nos. 22983 | 70680).{48541} Aceclofenac inhibits the production of prostaglandin E2 (PGE2; Item No. 14010) and thromboxane B2 (TXB2; Item No. 19030) by 25
库存:
1 g, 10 g, 25 g, 5 g
供应商:
Cayman
CAS号:
89796-99-6
An NSAID; selectively inhibits human COX-2 (IC50 = 0.8 μM) over COX-1 (IC50 = >100 μM) in isolated whole blood; inhibits PGE2 production in patient-derived human rheumatoid synovial cells (IC50s = 1.9-29.4 nM); reduces IL-1β-induced increases in IL-6 production by 21 and 43% in cultured chondrocytes without and with osteoarthritic lesions, respectively, at 30 μM; inhibits carrageenan-induced paw edema (ED50 = 3.6 mg/kg) and abscess formation (ED30 = 1.1 mg/kg) in rats; inhibits an increase in joint diameter in a rat model of CFA-induced arthritis