4BP-TQS is an allosteric agonist of α7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs).{47588} It activates human α7 subunit-containing nAChRs expressed in X. laevis oocytes more potently than acetylcholine (Item No. 23829; EC50s
库存:
1 mg, 10 mg, 25 mg, 5 mg
供应商:
Cayman
CAS号:
360791-49-7
An allosteric agonist of α7 subunit-containing nAChRs; activates human α7 subunit-containing nAChRs expressed in X. laevis oocytes more potently than acetylcholine (EC50s = 17 and 128 µM, respectively); selective for α7 subunit-containing nAChRs, having no activity for α1β1δε-, α3β4-, and α4β2 subunit-containing nAChRs at 100 µM; potentiates acetylcholine-induced activation of α7 subunit-containing nAChRs by greater than 540-fold in X. laevis oocytes at 10 µM; activates wild-type α7 subunit-containing nAChRs and nAChRs containing the α7 subunit and W148F, but not M253L, mutations in X. laevis oocytes