Mycophenolic acid is an immunosuppresive microbial metabolite that has been found in P. brevicompactum.{33309,33311} It is also an active metabolite of mycophenolate mofetil (Item No. 13988) that is formed via carboxylesterase 1 (CES1) and CES2.{57837}
英文名:
MPA|NSC 129185
库存:
100 mg, 25 mg, 50 mg
供应商:
Cayman
CAS号:
24280-93-1
规格:
This biochemical is available in the following size(s) 500 mg - Please inquire
An immunosuppressive microbial metabolite; an active metabolite of mycophenolate mofetil; inhibits IMPDH type I and type II (IC50s = 32 and 11 nM, respectively, in cell-free assays); inhibits DNA synthesis in L strain mouse fibroblasts at 0.1-10 µg/ml; active against several strains of C. albicans, C. parakrusei, C. tropicalis, and C. neoformans (MICs = 3.9-31.25 µg/ml), as well as various strains of S. aureus (MICs = 31.25-125 µg/ml); reduces splenomegaly in a mouse model of Friend virus-induced leukemia at 150 mg/kg; decreases the number of hemolytic plaque forming cells isolated from the spleen of mice immunized with sheep RBCs at 60-240 mg/kg