PX-13-17OH is a PI3K inhibitor.{18123} It selectively inhibits PI3Kα, PI3Kβ, PI3Kɣ, and PI3Kδ (IC50s = 6.4, 13, 8, and 11 nM, respectively) over mTOR (IC50 = 2.9 µM). PX-13-17OH is greater than 420-fold selective for PI3K in a panel of 20 lipid and prot
库存:
1 mg, 10 mg, 5 mg
供应商:
Cayman
CAS号:
884539-95-1
规格:
This biochemical is available in the following size(s) 1 mg, 10 mg, 5 mg - Please inquire
A PI3K inhibitor; inhibits PI3Kα, PI3Kβ, PI3Kɣ, and PI3Kδ (IC50s = 6.4, 13, 8, and 11 nM, respectively) over mTOR (IC50 = 2.9 µM); 420-fold selective for PI3K in a panel of 20 lipid and protein kinases; inhibits phosphorylation of Akt and S6K in PTEN-negative U87MG cells at 0.03-1 µg/ml; inhibits tumor growth in a U87MG mouse xenograft model at 2.5-10 mg/kg