BAY-2402234 is an inhibitor of dihydroorotate dehydrogenase (DHODH; IC50 = 1.2 nM).{57525} It induces upregulation of the cell differentiation marker CD11b in MOLM-13 and HEL acute myeloid leukemia (AML) cells (EC50s = 3.16 and 0.96 nM, respectively) an
库存:
1 mg, 10 mg, 25 mg, 5 mg
供应商:
Cayman
CAS号:
2225819-06-5
A DHODH inhibitor (IC50 = 1.2 nM); induces CD11b upregulation in MOLM-13 and HEL AML cells (EC50s = 3.16 and 0.96 nM, respectively); inhibits the proliferation of nine leukemia cell lines (IC50s = 0.08-8.2 nM); induces cell cycle arrest at the G2/M phase and apoptosis in TF-1 cells; reduces tumor volume in an MV4-11 mouse xenograft model at 1.25, 2.5, and 5 mg/kg; increases survival in PDX mouse models of AML