PDE4B inhibitor is an inhibitor of phosphodiesterase 4B (PDE4B; IC50 = 140 nM).{60155,60156} It is selective for PDE4B over a panel of 20 PDE isoforms and a panel of 39 CNS receptors at 10 µM but does inhibit the activity of PDE4C1, PDE3B, the serotonin
英文名:
KVA-D-88
库存:
1 mg, 10 mg, 25 mg, 5 mg
供应商:
Cayman
CAS号:
2410550-31-9
A PDE4B inhibitor (IC50 = 140 nM); selective for PDE4B over a panel of 20 PDE isoforms and a panel of 39 CNS receptors at 10 µM; inhibits the activity of PDE4C1, PDE3B, 5-HT2C, and σ2 receptor by >50% activity at 10 µM; decreases LPS- or Pam3Cys-induced TNF-α production in mouse BMDMs at 1 µM; reduces cocaine self-administration and the progressive ratio breakpoint in mice at 5 mg/kg