CDN1163 is an allosteric activator of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2 (SERCA2) that enhances calcium uptake in endoplasmic reticulum (ER) vesicles when used at concentrations ranging from 1 to 10 µM.{57074} It decreases peroxide-induced
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An allosteric activator of SERCA2; enhances calcium uptake in ER vesicles from 1-10 µM; decreases peroxide-induced cell death in HEK293 cells; increases calcium uptake in ER microsomes isolated from obese mouse liver at 50 mg/kg; decreases blood glucose levels, plasma and hepatic triglyceride levels, and plasma cholesterol and MDA levels in obese mice at 50 mg/kg; restores SERCA activity, prevents gastrocnemius muscle loss and contractile dysfunction, and reduces mitochondrial production of ROS in the Sod-/- mouse model of oxidative stress-related muscle atrophy and weakness; improves motor deficits in the IT, stepping, and cylinder tests for akinesia in a rat model of 6-OHDA-induced Parkinson's disease