CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS; IC50 = 0.45 µM).{56106} It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 (IRF3; Item No. 22811) in THP-1 cells, indicating selectivity for the cGAS DN
库存:
1 mg, 10 mg, 5 mg
供应商:
Cayman
CAS号:
2400954-16-5
A cGAS inhibitor (IC50 = 0.45 µM); reduces DNA-, but not Sendai virus-, induced IRF3 dimerization in THP-1 cells, indicating cGAS pathway selectivity; selective for cGAS over TLRs at 50 µM; decreases IFN-stimulatory DNA-induced IFN-β production in THP-1 cells at 10, 30, and 100 µM