NLRP3i is an intermediate in the synthesis of glyburide (Item No. 15009) and an inhibitor of the NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome.{54178} It is selective for NLRP3 over NLRP4 and absent in melanoma 2 (AIM2) inflamma
库存:
1 g
供应商:
Cayman
CAS号:
16673-34-0
An NLRP3 inflammasome inhibitor; selective for NLRP3 over NLRP4 and AIM2 inflammasomes at 400 µM; inhibits LPS-induced IL-1β release and ASC oligomerization in J774A.1 mouse macrophages; reduces infarct size and cardiac levels of troponin I in a mouse model of acute myocardial infarction at 100 mg/kg; reduces peritoneal leukocyte infiltration in a mouse model of zymosan A-induced peritonitis; decreases plasma IL-18 levels and reduces systolic and diastolic dysfunction in a mouse model of Western diet-induced obesity at 100 mg/kg