TNP is a cell-permeable inhibitor of inositol-1,4,5-trisphosphate 6-kinase 1 (IP6K1; IC50 = 0.55 µM; Ki = 0.24 µM) and IP3K (IC50 = 10.2 µM; Ki = 4.3 µM) that binds to the ATP-binding sites of both enzymes. {38146,38145} TNP reduces IP7 and IP8 levels (
英文名:
IP3K Inhibitor|IP6K Inhibitor
库存:
1 mg, 10 mg, 5 mg, 50 mg
供应商:
Cayman
CAS号:
519178-28-0
规格:
This biochemical is available in the following size(s) 10 mg, 5 mg, 50 mg - Please inquire
An IP6K (IC50 = 0.55 µM; Ki = 0.24 µM) and IP3K (IC50 = 10.2 µM; Ki = 4.3 µM) inhibitor; reduces IP7 and IP8 levels; inhibits insulin release in MIN6 cells; increases intracellular calcium levels in a concentration-dependent manner (5-20 µM) in HL-60 cells; increases intracellular calcium and induces degranulation of mast cells