BI-78D3 is an inhibitor of JNK (IC50 = 280 nM in a TR-FRET assay) that is competitive for JNK1 binding with pepJIP1, a JNK-interacting protein, with an IC50 value of 500 nM.{38279} It is selective for JNK, being 100-fold less active for the structurally
英文名:
c-Jun N-terminal Kinase Inhibitor X|JNK Inhibitor X
库存:
1 mg, 10 mg, 25 mg, 5 mg
供应商:
Cayman
CAS号:
883065-90-5
规格:
This biochemical is available in the following size(s) 10 mg, 25 mg, 5 mg - Please inquire
An inhibitor of JNK (IC50 = 280 nM); competitive for JNK1 binding with pepJIP1 (IC50 = 500 nM); selective for JNK over p38α, mTOR, and PI3Kα; inhibits c-Jun phosphorylation induced by TNF-α (EC50 = 12.4 µM); restores insulin sensitivity in a mouse model of type 2 diabetes when administered at 25 mg/kg 30 minutes prior to insulin; reduces human prostate strip contractions induced by phenylephrine or norepinephrine when applied at 30 µM and reduces phosphorylation of c-Jun, a JNK substrate