GNF-7 is a multi-kinase inhibitor (IC50s = 25, 8, 61, 122, 136, and 133 nM for ACK1, GCK, Bcr-AblT315I, Bcr-AblE255V, Bcr-AblG250E, and c-Abl, respectively).{45192,45193} It also inhibits several additional kinases in a panel by greater than 50% when us
库存:
1 mg, 10 mg, 25 mg, 5 mg
供应商:
Cayman
CAS号:
839706-07-9
规格:
This biochemical is available in the following size(s) 10 mg, 25 mg, 5 mg - Please inquire
A multi-kinase inhibitor (IC50s = 25, 8, 61, 122, 136, and 133 nM for ACK1, GCK, Bcr-AblT315I, Bcr-AblE255V, Bcr-AblG250E, and c-Abl, respectively); inhibits the growth of Ba/F3 cells transformed with wild-type Bcr-Abl, Bcr-AblT315I, Bcr-AblE255V, and Bcr-AblG250E (IC50s = 50s = 1 and 5 nM, respectively); reduces tumor growth in a Bcr-AblT315I Ba/F3 mouse xenograft model at 10 and 20 mg/kg; reduces tumor volume in an OCI-AML3 mouse xenograft model at 8 mg/kg