Ceritinib is an inhibitor of anaplastic lymphoma kinase (ALK; IC50 = 0.2 nM).{48716} It is selective for ALK over IGF-1R, InsR, STK22D, and FLT3 (IC50s = 8, 7, 23, and 60 nM, respectively) as well as a panel of 25 additional kinases (IC50s = >0.26 μM fo
英文名:
LDK 378
库存:
1 mg, 10 mg, 25 mg, 5 mg
供应商:
Cayman
CAS号:
1032900-25-6
规格:
This biochemical is available in the following size(s) 1 mg, 10 mg, 5 mg - Please inquire
An ALK inhibitor (IC50 = 0.2 nM); selective for ALK over IGF-1R, InsR, STK22D, and FLT3 (IC50s = 8, 7, 23, and 60 nM, respectively) as well as a panel of 25 additional kinases (IC50s = >0.26 μM for all); inhibits the proliferation of Ba/F3 cells expressing the fusion protein NPM-ALK or ELM4-ALK (IC50s = 0.02 and 0.021 μM, respectively), as well as several crizotinib-resistant NPM-ALK and ELM4-ALK mutants; reduces tumor growth in an H2228 NSCLC rat xenograft model at 10 mg/kg per day and induces tumor regression at 25 mg/kg per day; induces tumor regression in a Karpas299 lymphoma rat xenograft model at 25 and 50 mg/kg per day