XMD8-92 is an ERK5 inhibitor (Kd = 80 nM) that less potently inhibits DCAMKL2, TNK1, and Plk4 (Kds = 190, 890, and 600 nM, respectively) in a panel of 402 kinases.{31129} It blocks ERK5 autophosphorylation, ERK5-mediated phosphorylation of promyelocytic
库存:
1 mg, 10 mg, 25 mg, 5 mg
供应商:
Cayman
CAS号:
1234480-50-2
规格:
This biochemical is available in the following size(s) 10 mg, 25 mg, 5 mg - Please inquire
A selective ERK5 inhibitor (Kd = 80 nM); less potently inhibits DCAMKL2, TNK1, and Plk4 (Kds = 190, 890, and 600 nM, respectively); blocks ERK5 autophosphorylation, ERK5-mediated phosphorylation of PML, and PML-dependent activation of p21; inhibits bFGF-induced angiogenesis in a Matrigel™ plug assay in mice; reduces tumor growth in a HeLa mouse xenograft model at 50 mg/kg twice per day; binds BRD4 (Kd = 170 nM for BRD4 bromodomain 1)