KT185 is an orally bioavailable inhibitor of α/β-hydrolase domain-containing protein 6 (ABHD6) with an IC50 value of 0.21 nM in a competitive activity-based protein profiling assay using Neuro2A membranes.{24855} It inhibits ABHD6 in a 2-arachidonoyl gl
库存:
10 mg, 25 mg, 5 mg, 50 mg
供应商:
Cayman
CAS号:
1472640-86-0
An inhibitor of ABHD6 (IC50 = 0.21 nM in Neuro2A cells); inhibits ABHD6 in a 2-AG hydrolysis assay (IC50 = 13.6 nM for the mouse recombinant enzyme expressed in HEK293T cells); selective for ABHD6 over DAGLβ at 1 µM but inhibits LYPLA1 and LYPLA2 at 10 µM; inhibits ABHD6 activity in mouse liver and brain in vivo at 5-10 and ~40 mg/kg, respectively; inhibits nicotine-induced increases in sIPSC frequency in the rat VTA but does not reduce nicotine self-administration in rats at 200 µg; has been used as a negative control for the off-target effect of KT172 on ABHD6