Thromboxane (TXA2) activates the T prostanoid (TP) receptor. Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. AH 23848 is a dual antagonist of TP and EP4 receptors.{3339,1755} It originally was found to inhibit TXA2-induced pla
库存:
1 mg, 10 mg, 25 mg, 5 mg
供应商:
Cayman
CAS号:
81496-19-7
A dual antagonist of TP and EP4 receptors; inhibits TXA2-induced platelet aggregation (IC50 = 0.26 μM) and bronchial smooth muscle contraction; impairs PGE2-mediated relaxation of piglet saphenous vein, suppresses serum-induced proliferation of fibroblasts, and reduces metastasis in a mouse model of breast cancer