ASP3026 is an inhibitor of anaplastic lymphoma kinase (ALK; IC50s = 3.5, 10, and 5.4 nM for the wild-type, ALKF1174L, and ALKR1275Q enzymes, respectively).{29825} It is selective for ALK over a panel of 86 kinases at 1,000 nM but also inhibits c-Ros onc
库存:
1 mg, 10 mg, 25 mg, 5 mg
供应商:
Cayman
CAS号:
1097917-15-1
规格:
This biochemical is available in the following size(s) 10 mg, 25 mg, 5 mg - Please inquire
An ALK inhibitor (IC50s = 3.5, 10, and 5.4 nM for the wild-type, ALKF1174L, and ALKR1275Q enzymes, respectively); selective for ALK over a panel of 86 kinases at 1,000 nM but also inhibits ROS1 and TNK2 (IC50s = 8.9 and 5.8 nM, respectively); inhibits the proliferation of Ba/F3 cells expressing NPM-ALK or ELM4-ALK fusion proteins (IC50s = 84 and 56 nM, respectively), as well as several crizotinib-resistant Ba/F3 cells expressing NPM-ALK or ELM4-ALK mutants; induces tumor regression in an NCI H2228 NSCLC mouse xenograft model at 10 and 30 mg/kg