RTA 408 is a synthetic triterpenoid that binds Keap1 and attenuates the degradation of Nrf2 at concentrations ≤25 nM.{29061} In this way, it suppresses the generation of nitric oxide and pro-inflammatory cytokines in macrophages stimulated with IFN-γ.{2
英文名:
Omaveloxolone
库存:
1 mg, 10 mg, 25 mg, 5 mg
供应商:
Cayman
CAS号:
1474034-05-3
Binds Keap1 and attenuates the degradation of Nrf2 at concentrations ≤25 nM, suppressing inflammatory signaling; inhibits tumor cell growth (GI50 = 260 nM), blocks NF-κB signaling, and decreases levels of cyclinD1; activates Nrf2 and provides cytoprotective effects when applied topically