LP99 is a potent inhibitor of the bromodomain containing proteins BRD7 and BRD9 that binds with Kd values of 99 and 909 nM, respectively, as determined by isothermal titration calorimetry.{38168,31210} It is selective for BRD7/9 over a panel of 48 BRDs
库存:
1 mg, 5 mg, 500 µg
供应商:
Cayman
CAS号:
1808951-93-0
A selective inhibitor of BRD7 and BRD9 (Kds = 99 and 909 nM, respectively); selective for BRD7/9 over a panel of 48 BRDs up to 10 µM; inhibits BRD7 interactions with H3.3 and H4 (IC50s = 3.7 and 3.3 µM, respectively); inhibits BRD9 interactions with H3.3 and H4 (IC50s = 5.1 and 6.2 µM, respectively); decreases IL-6 levels in LPS-stimulated THP-1 cells