MK2a inhibitor is a substrate-selective inhibitor of p38α MAPK that selectively inhibits p38α-dependent phosphorylation of MAPKAPK-2 (MK2) over activating transcription factor 2 (ATF2; Kiapps = 330 and >20,000 nM, respectively, in cell-free assays).{465
英文名:
CMPD 1
库存:
1 mg, 10 mg, 5 mg, 50 mg
供应商:
Cayman
CAS号:
41179-33-3
规格:
This biochemical is available in the following size(s) 100 g, 25 g, 5 g - Please inquire
A substrate-selective p38α MAPK inhibitor; selectively inhibits p38α-dependent phosphorylation of MK2 over ATF2 (Kiapps = 330 and >20,000 nM, respectively, in cell-free assays); inhibits proliferation of U87, A172, and U251 glioblastoma cells (EC50s = 0.6-1 μM) via inhibition of tubulin polymerization and induction of apoptosis