Binimetinib is an orally bioavailable inhibitor of MEK1/2 (IC50 = 12 nM).{27962} It has been found to inhibit ERK phosphorylation in various cancer cell lines (IC50s ≥ 5 nM).{27962} This compound is efficacious in several xenograft tumor models in mice,
英文名:
ARRY-438162|MEK162
库存:
10 mg, 100 mg, 5 mg, 50 mg
供应商:
Cayman
CAS号:
606143-89-9
规格:
This biochemical is available in the following size(s) 1 mg, 5 mg, 500 µg - Please inquire
An orally bioavailable inhibitor of MEK1/2 (IC50 = 12 nM) that inhibits ERK phosphorylation in various cancer cell lines (IC50s ≥ 5 nM); efficacious in several xenograft tumor models in mice, including those bearing K-Ras or B-RAF mutations, as well as in clinical studies using patients with N-Ras melanoma, non-small cell lung cancer, or biliary tract cancer