Janus kinases (JAKs) are non-receptor kinases that mediate signaling through cytokine receptors, often to members of the signal transducer and activator of transcription family.{20362} CEP-33779 is a potent, orally available inhibitor of JAK2 (IC50 = 1.3
库存:
1 mg, 5 mg, 500 µg
供应商:
Cayman
CAS号:
1257704-57-6
规格:
This biochemical is available in the following size(s) 1 mg, 10 mg, 5 mg - Please inquire
A potent, orally available inhibitor of JAK2 (IC50 = 1.3 nM); reduces the production of inflammatory cytokines and blocks disease development in mouse models of lupus and arthritis; induces regression of established colorectal tumors in mice, reducing angiogenesis and proliferation of tumor cells