Sotrastaurin is a protein kinase C (PKC) inhibitor that displays immunosuppressive activity, blocking T cell activation through the disruption of downstream NF-κB signaling.{27221,27224} In cell-free assays, sotrastaurin was reported to inhibit PKCα, βI
英文名:
AEB071
库存:
1 mg, 10 mg, 5 mg
供应商:
Cayman
CAS号:
425637-18-9
规格:
This biochemical is available in the following size(s) 10 mg, 5 mg, 500 µg - Please inquire
A PKC inhibitor that displays immunosuppressive activity, blocking T cell activation through the disruption of downstream NF-κB signaling; inhibits PKCα, βI, δ, ε, η, and θ with Ki values of 0.95, 0.64, 2.1, 3.2, 1.8, and 0.22 nM, respectively; also inhibits GSK3α and GSK3β (IC50s = 229 and 172 nM, respectively), which activates Wnt/β-catenin signaling and is important for adult stem cell maintenance