In humans, two forms of diacylglycerol lipase, DAGLα and DAGLβ, generate the endocannabinoid 2-arachidonoyl glycerol (2-AG; Item No. 62160) by attacking DAG at the sn-1 position. LEI-106 is a potent in vitro inhibitor of sn-1 DAGLα (IC50 = 18 nM).{26613}
库存:
1 mg, 10 mg, 25 mg, 5 mg
供应商:
Cayman
CAS号:
1620582-23-1
A potent in vitro inhibitor of sn-1 DAGLα (IC50 = 18 nM); blocks the hydrolysis of sn-1-oleoyl-2-AG, the natural substrate of DAGLα, with a Ki value of 0.7 µM; inhibits the hydrolysis of 2-AG by the monoacylglycerol lipase ABHD6 in membrane preparations (Ki = 0.8 µM)