TG101348 is a JAK2 inhibitor (IC50 = 3 nM for wild-type and JAK2V617F enzymes).{61888} It is 35-, 334-, and 135-fold selective for JAK2 over JAK1, JAK3, and tyrosine kinase 2 (TYK2), respectively. It is also selective for JAK2 over a panel of 34 kinases
英文名:
Fedratinib|SAR302503
库存:
1 mg, 10 mg, 25 mg, 5 mg
供应商:
Cayman
CAS号:
936091-26-8
规格:
This biochemical is available in the following size(s) 10 mg, 25 mg, 5 mg - Please inquire
A JAK2 inhibitor (IC50 = 3 nM for wild-type and JAK2V617F enzymes); is 35-, 334-, and 135-fold selective for JAK2 over JAK1, JAK3, and TYK2, respectively; selective for JAK2 over a panel of 34 kinases at 500 nM; inhibits FLT3 and RET (IC50s = 15 and 48 nM, respectively); reduces the proliferation of HEL cells as well as Ba/F3 murine cells expressing JAK2V617F (IC50s = 305 and 270 nM, respectively); inhibits the differentiation of hematopoietic stem cells and myeloid progenitor cells isolated from patients with polycythemia vera at 300 nM; improves survival and reduces spleen weight in a syngeneic mouse model of polycythemia vera induced by transplantation of Jak2V617F-expressing whole bone marrow at 60 and 120 mg/kg