Sorafenib N-oxide is an active metabolite of sorafenib (BAY 43-9006; Item No. 10009644), an inhibitor of Raf-1, B-RAF, and receptor tyrosine kinases.{48271} Sorafenib N-oxide inhibits FLT3 that contains the internal tandem duplication mutation (FLT3-ITD
英文名:
BAY 67-3472
库存:
1 mg, 5 mg
供应商:
Cayman
CAS号:
583840-03-3
规格:
This biochemical is available in the following size(s) 10 mg, 25 mg, 5 mg - Please inquire
An active metabolite of sorafenib; inhibits FLT3-ITD (Kd = 70 nM); inhibits proliferation of MV4-11 AML cells expressing FLT3-ITD (IC50 = 25.8 nM); selective for AML cell lines containing FLT3-ITD over lines containing wild-type FLT3 (IC50s = 3.9-13.3 µM); a linear-mixed inhibitor of CYP3A4 (Ki = 15 µM)