Tegafur is an orally bioavailable prodrug form of 5-fluorouracil (5-FU; Item No. 14416).{46033} It is converted to 5-FU in vivo enzymatically or by cytochrome P450 oxidation. Tegafur inhibits proliferation of HT-29, BxPC-3, and Panc02 cells (IC50s = 201
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A prodrug form of 5-fluorouracil; inhibits proliferation of HT-29, BxPC-3, and Panc02 cells (IC50s = 201, 172, and 179 µM, respectively); reduces tumor growth in an HT-27 colon carcinoma mouse xenograft model at 50 mg/kg and in a 4-1ST gastric carcinoma mouse xenograft model when used in combination with uracil