Penfluridol is a first generation typical antipsychotic that binds to dopamine receptors (IC50 = 5.6 nM).{42533} It binds to dopamine D4 receptors and also to serotonin (5-HT) receptors (Kis = 31 and 63.1 nM, respectively).{42534,42535} Penfluridol (1.2
英文名:
R-16341
库存:
1 g, 100 mg, 250 mg, 500 mg
供应商:
Cayman
CAS号:
26864-56-2
A typical antipsychotic; binds to dopamine receptors (IC50 = 5.6 nM); binds to dopamine D4 and 5-HT receptors (Kis = 31 and 63.1 nM, respectively); inhibits stereotypic behavior induced by apomorphine in cynomolgus monkeys at 1.25 and 2.5 mg/kg; inhibits proliferation of TNBCs (IC50s = 6-8 µM); inhibits migration and invasion of TNBCs and decreases the expression of integrin α6 and β4; reduces tumor growth and metastasis in a 4T1 orthotopic mouse model at 10 mg/kg per day