Imperatorin is a furanocoumarin that has been found in A. dahurica and has diverse biological activities, including anticancer, anti-inflammatory, and antioxidant properties.{47081,47082,47083} It decreases MCL-1 protein levels and increases mitochondri
英文名:
Marmelosin|NSC 402949
库存:
10 mg, 100 mg, 25 mg, 50 mg
供应商:
Cayman
CAS号:
482-44-0
规格:
This biochemical is available in the following size(s) 25 mg, 250 mg, 50 mg - Please inquire
A furanocoumarin with diverse biological activities; decreases MCL-1 protein levels and increases mitochondrial membrane depolarization and apoptosis in R-HepG2 cells, an effect that can be reversed by overexpression of MCL-1; inhibits the growth of doxorubicin-resistant and -sensitive HepG2 cells (IC50s = 28.1 and 43.3 μM, respectively); reduces tumor growth in an R-HepG2 mouse xenograft model at 50 mg/kg; inhibits LPS-induced increases in p38 MAPK, JNK, and IκBα phosphorylation, TNF-α, IL-6, and IL-1β protein levels, and nuclear localization of NF-κB p65 in RAW 264.7 macrophages; scavenges DPPH and ABTS radicals (EC50s = 19.48 and 10.93 μM, respectively); has antibacterial, antiviral, and anticonvulsant activities