(±)10(11)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 0.43 and 22.5 nM for CB1 and CB2 receptors, respectively).{42488} It is produced though direct epoxygenation of docosahexaenoyl ethanolamide (DHE
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An ω-3 endocannabinoid epoxide and CB receptor agonist (EC50s = 0.43 and 22.5 nM for CB1 and CB2 receptors, respectively); reduces the viability of 143B metastatic osteosarcoma cells at 12.5 and 25 μM; induces apoptosis and inhibits cell migration in a wound-healing assay in 143B, MG63, and HOS osteosarcoma cells; reduces tube formation by HUVECs in a Matrigel™ assay