CA-074 is a selective epoxysuccinyl peptide inhibitor of the cysteine protease cathepsin B (Kis = 0.0087, 75, and 233 μM for rat cathepsin B, H, and L, respectively).{14250} It inhibits degradation of DQ-collagen IV and DQ-collagen I in 4T1.2 breast can
库存:
1 mg, 500 µg
供应商:
Cayman
CAS号:
134448-10-5
A selective cathepsin B inhibitor (Kis = 0.0087, 75, and 233 μM for rat cathepsin B, H, and L, respectively); inhibits degradation of DQ-collagen IV and DQ-collagen I in 4T1.2 breast cancer cells; reduces the number of lung and bone metastases in a 4T1.2 murine mammary cancer model at 50 mg/kg; reduces mercury-induced increases in expression of TNF-α, IL-1β, and the inflammasome component NRLP3 and decreases the severity of mercury-induced skin induration in mice at 0.1 and 0.2 mg/kg; reduces ischemia-induced hippocampal neuron cell death in monkeys