α-Calcitonin gene-related peptide (α-CGRP) is a neuropeptide with diverse biological activities.{41395} It belongs to the calcitonin family of peptides, which also includes amylin (Item No. 24274), calcitonin (Item Nos. 24409 | 24410), and adrenomedulli
英文名:
Calcitonin Gene Related Peptide-1 (human)|CGRP-1 (human)|α-Calcitonin Gene-Related Peptide (human)
库存:
1 mg, 500 µg
供应商:
Cayman
规格:
This biochemical is available in the following size(s) 5 mg - Please inquire
A neuropeptide with diverse biological activities; binds selectively to CRLR-RAMP1 complexes (IC50 = 0.1 nM) over a complex of CLCR-RAMP2 (IC50 = 1,300 nM) binds selectively to CTR2-RAMP1 (IC50 = 43.7 nM) compared to CTR2-RAMP2 (IC50 = 141.3 nM) in amylin radioligand displacement assays; induces cAMP-activated currents in Xenopus oocytes with endogenous Cgrp receptors that overexpress RAMP1 (EC50 = 9 nM); induces cAMP accumulation in COS-7 cells transfected with both CTR2 and RAMP1 (EC50 = 8.32 nM)