MK-0974 is an orally bioavailable antagonist of the calcitonin gene-related peptide (CGRP) receptor complex (Ki = 0.77 μM), which is composed of the calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein 1 (RAMP1).{38703} MK-09
库存:
1 mg, 10 mg, 5 mg
供应商:
Cayman
CAS号:
781649-09-0
规格:
This biochemical is available in the following size(s) 100 mg, 250 mg, 500 mg - Please inquire
A CGRP receptor antagonist (Ki = 0.77 μM); binds selectively to the human CGRP receptor complex over the adrenomedullin receptor complexes in HEK293 cells (Kis = >100 and 29 μM for CRLR with RAMP2 and 3, respectively); inhibits CGRP-induced cAMP accumulation in HEK293 cells expressing the CGRP receptor complex (IC50 = 2.2 nM); reduces CGRP-induced vasodilation in isolated human meningeal arteries; inhibits vasodilation induced by topical application of capsaicin in rhesus monkeys (EC50 = 127 nM)