GBT-440 is a modulator of sickle hemoglobin (HbS) that binds covalently to the N-terminal valine of the α chain of HbS.{41378} In vitro, GBT-440 increases HbS affinity for oxygen (EC50s = 8.2 and 415 μM for purified HbS and whole blood from sickle cell
英文名:
Voxelotor
库存:
1 mg, 10 mg, 25 mg, 5 mg
供应商:
Cayman
CAS号:
1446321-46-5
A modulator of sickle hemoglobin; increases HbS affinity for oxygen (EC50s = 8.2 and 415 μM for purified HbS and whole blood from sickle cell anemia patients, respectively); delays oxygen release from and polymerization of HbS in a concentration-dependent manner; increases red blood cell half-life and reduces sickling ex vivo in whole blood isolated from a murine model of sickle cell anemia