D,L-Buthionine-(S,R)-sulfoximine is an inhibitor of γ-glutamylcysteine synthetase that induces 100% inhibition at a concentration of 10 μM in an enzyme assay.{36246} It is selective for γ-glutamylcysteine synthetase, lacking activity at glutamine synthe
英文名:
NSC 381100
库存:
1 g, 250 mg, 5 g, 500 mg
供应商:
Cayman
CAS号:
5072-26-4
A γ-glutamylcysteine synthetase inhibitor (100% inhibition at a concentration of 10 μM in an enzyme assay); selective for γ-glutamylcysteine synthetase, lacking activity at glutamine synthetase at concentrations up to 500 μM; reduces renal glutathione in mice without inducing abnormal behavior or convulsions at a dose of 32 mmol/kg; eliminates T. brucei from the bloodstream of infected mice via depletion of intratrypanosomal glutathione and induction of oxidative stress at a dose of 4 mmol/kg; an isomeric mixture of L-buthionine-S-sulfoxime, L-buthionine-R-sulfoxime, D-buthionine-S-sulfoxime, and D-buthionine-R-sulfoxime