CPI-637 is an inhibitor of cyclic-AMP response element binding protein (CBP) and adenoviral E1A binding protein of 300 kDa (EP300), a homologous pair of bromodomain-containing proteins (IC50s = 30 and 51 nM in a time-resolved-FRET (TR-FRET) assay).{404
库存:
1 mg, 10 mg, 25 mg, 5 mg
供应商:
Cayman
CAS号:
1884712-47-3
An inhibitor of CBP/EP300 bromodomains (IC50s = 30 and 51 nM in a TR-FRET assay); selective for CBP and EP300 over the BET family of bromodomains (IC50s = >10 μM); is active at bromodomain BRD9 (IC50 = 0.73 μM); inhibits CBP (IC50 = 0.3 μM in a BRET assay) and inhibits MYC expression (EC50 = 0.6 μM) in AMO-1 cells