APD597 is an orally bioavailable agonist of GPR119 that has EC50 values of 46 and 421 nM for the human and rat receptors, respectively, in a homologous time-resolved fluorescence (HTRF) assay.{48588} It increases insulin secretion stimulated by a high,
英文名:
JNJ-38431055
库存:
10 mg, 25 mg, 5 mg, 50 mg
供应商:
Cayman
CAS号:
897732-93-3
An agonist of GPR119 (EC50s = 46 and 421 nM for the human and rat receptors, respectively, in an HTRF assay); increases high glucose-induced insulin secretion in isolated mouse pancreatic β-cells and isolated human islets; increases glucose-induced GLP-1 levels in mice at 20 mg/kg; decreases blood glucose levels in an oral glucose tolerance test in mice at 1 and 10 mg/kg and in Zucker diabetic rats at 3 mg/kg