YM-298198 is a non-competitive antagonist of the metabotropic glutamate receptor type I (mGluR1; Ki = 19 nM).{38955} It is selective for mGluR1 over mGluR2-7 (IC50s = 0.016 and >10 μM, respectively). YM-298198 binds to rat cerebellum membranes (Ki = 20
库存:
1 mg, 10 mg, 25 mg, 5 mg
供应商:
Cayman
CAS号:
1216398-09-2
A non-competitive antagonist of mGluR1 (Ki = 19 nM); selective for mGluR1 over mGluR2-7 (IC50s = 0.016 and >10 μM, respectively); increases nociceptive response latency in a mouse model of streptozotocin-induced hyperalgesia (10 and 30 mg/kg, p.o.); reduces reinstatement of drug-seeking behavior induced by cocaine priming in rats