BMS 582949 is an orally bioavailable p38α MAP kinase inhibitor (IC50 = 13 nM in an enzyme assay).{39188} It also inhibits TNF-α production in human peripheral blood mononuclear cells (PBMC; IC50 = 50 nM). When administered at a dose of 5 mg/kg in mice,
库存:
1 mg, 25 mg, 5 mg
供应商:
Cayman
CAS号:
623152-17-0
规格:
This biochemical is available in the following size(s) 10 g, 5 g, 50 g - Please inquire
A p38α MAP kinase inhibitor (IC50 = 13 nM); inhibits TNF-α production in PBMCs (IC50 = 50 nM); reduces LPS-induced TNF-α production up to 89% in mice at 5 mg/kg; reduces paw swelling in a rat adjuvant arthritis model when administered once per day (1, 10, or 100 mg/kg) or twice per day (1 or 5 mg/kg)