SN-38 is the active metabolite of irinotecan (Item No. 14180), a derivative of the alkaloid camptothecin (Item No. 11694), and acts as a potent inhibitor of DNA topoisomerase I.{21114,21115} It is formed by the hydrolysis of irinotecan by carboxylestera
This biochemical is available in the following size(s) 10 mg, 25 mg, 5 mg - Please inquire
The active metabolite of irinotecan that potently inhibits DNA topoisomerase I; more cytotoxic to HT-29 colon cancer cells (IC50 = 8.8 nM) compared to irinotecan (IC50 > 100 nM)