Ubiquitin-specific proteases (USP/UBP) remove ubiquitin from proteins, sparing them from degradation by the proteasome. USP7 is a cysteine protease associated with prostate cancer that selectively deubiquitylates HDM2, the ubiquitin E3 ligase for the tum
英文名:
P5091
库存:
10 mg, 25 mg, 5 mg, 50 mg
供应商:
Cayman
CAS号:
882257-11-6
A trisubstituted thiophene that selectively inhibits USP7 and the closely related USP47 (EC50s = 4.2 and 4.3 μM, respectively); accelerates the degradation of the USP7 substrate HDM2 in several multiple myeloma cell lines (EC50 =11 μM)