Cyclin-dependent kinase 1 (Cdk1) complexes with different cyclins, with the cyclin determining substrate specificity. Ro 3306 is a cell-permeable, reversible inhibitor of Cdk1, showing preference for Cdk1/cyclin B1 (Ki = 35 nM) over Cdk1/cyclin A (Ki = 1
库存:
1 mg, 10 mg, 5 mg, 50 mg
供应商:
Cayman
CAS号:
872573-93-8
规格:
This biochemical is available in the following size(s) 25 mg, 5 mg, 50 mg - Please inquire
A cell-permeable, reversible inhibitor of Cdk1, showing preference for Cdk1/cyclin B1 (Ki = 35 nM) over Cdk1/cyclin A (Ki = 110 nM); also inhibits Cdk2 (Ki = 340 nM), PKCδ (Ki = 318 nM), and SGK (Ki = 497 nM) but not Cdk4; reversibly arrests proliferating cells at the G2/M phase border, allowing cell synchronization