PS-1145 is an IκB kinase β (IKKβ) inhibitor (IC50 = 88 nM).{23652} It selectively inhibits IKKβ over a panel of 14 kinases (IC50s = >100 nM for all). PS-1145 also inhibits the IKK complex (IC50 = 100 nM).{23654} It inhibits the proliferation of MM.1S, U
英文名:
IKK Inhibitor X
库存:
1 mg, 5 mg, 500 µg
供应商:
Cayman
CAS号:
431898-65-6
规格:
This biochemical is available in the following size(s) 1 mg, 5 mg, 500 µg - Please inquire
An IKKβ inhibitor (IC50 = 88 nM); selectively inhibits IKKβ over a panel of 14 kinases (IC50s = >100 nM for all); inhibits the IKK complex (IC50 = 100 nM); inhibits the proliferation of MM.1S, U266, and RPMI-8226 cells at 1.5-50 µM; inhibits TNF-α-induced activation of NF-κB in MM.1S cells; inhibits RANKL-induced osteoclast differentiation of RAW 264.7 cells into osteoclasts at 5 and 10 µM; inhibits RANKL-induced phosphorylation of IκBα, ERK, and JNK in RAW 264.7 cells at 10 µM