A-771726 is an active metabolite of the prodrug leflunomide (Item No. 14860) that inhibits dihydroorotate dehydrogenase (DHODH; IC50 = 0.23 µM).{60466} A-771726 inhibits the production of prostaglandin E2 (PGE2; Item No. 14010) in TNF-α- or IL-1α-stimul
英文名:
Flucyamide|HMR 1726|SU 20|Teriflunomide
库存:
10 mg, 25 mg, 5 mg
供应商:
Cayman
CAS号:
163451-81-8
An active metabolite of leflunomide; inhibits DHODH (IC50 = 0.23 µM); inhibits the production of PGE2 in TNF-α- or IL-1α-stimulated isolated human synoviocytes (IC50s = 7 and 3 μM, respectively); inhibits the proliferation of isolated human PBMCs at 25 and 100 µM; delays disease onset and decreases neurological deficits in a rat model of EAE induced by CFA and M. tuberculosis at 3 and 10 mg/kg