Axitinib is a VEGFR inhibitor (IC50s = 1.2, 0.25, and 0.29 nM for VEGFR1, -2, and -3, respectively).{18372} It also inhibits c-Kit and PDGFRβ (IC50s = 1.7 and 1.6 nM, respectively). It inhibits VEGF-induced migration of and tube formation by human umbil
英文名:
AG-013736
库存:
100 mg, 50 mg, 500 mg
供应商:
Cayman
CAS号:
319460-85-0
规格:
This biochemical is available in the following size(s) 10 mg, 5 mg, 500 µg - Please inquire
A VEGFR inhibitor (IC50s = 1.2, 0.25, and 0.29 nM for VEGFR1, -2, and -3, respectively); inhibits c-Kit and PDGFRβ (IC50s = 1.7 and 1.6 nM, respectively); inhibits VEGF-induced migration of and tube formation by HUVECs; reduces microvessel density, a marker of angiogenesis, and tumor growth in MV522 colon carcinoma, A375 melanoma, SN12C GFP renal carcinoma, and U87 glioma mouse xenograft models from 1-100 mg/kg